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doi: 10.1016/j.cmet.2012.07.002 134 TamJSzandaGDroriALiuZCinarRKashiwayaYet al

On the other hand, a number of studies suggest that in pharmacologic doses (10 mM), ascorbate exhibits anti-cancer effects and may have a potential for use in the treatment of cancer through the induction of both oxidative stress and DNA demethylation [160,161]

Detection of intracellular ROS and mitochondrial membrane potential in vitro Fluorescent probes 2,7-Dichlorodihydrofluoresce in diacetate (Solarbio, China) were used to detect intracellular ROS in cells